ChemInform Abstract: Three Component Reaction: An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Thiones Using Heterogeneous Catalyst

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    ChemInform 2010, 41, issue 30© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Pyrimidine derivativesR 0510DOI: 10.1002/chin.201030167 Three Component Reaction: An Efficient Synthesis of 3,4-Dihydropyrimidin--2(1H)-ones and Thiones Using Heterogeneous Catalyst.  — This procedure offers easy access to dihydropyrimidinones/thiones (IV) and (VII) with a variety of substitu-tion patterns by utilizing a three-component one-pot condensation of dicarbonyl com-pounds (I) and (V), aldehydes (II) and (VI), and urea/thiourea (III) in the presence of silica-supported fluoroboric acid. Aromatic aldehydes provide the corresponding dihy-dropyrimidinones in good to excellent yields with high purity. Aliphatic and α , β -un-saturated aldehydes which normally show low conversion in the Biginelli reaction, af-ford the corresponding target compounds in good yields. The feature of this procedure is the ability to tolerate a wide variety of functional groups like ether, nitro, hydroxy, olefin and halide under the reaction conditions. Acid-sensitive aldehydes such as (IIc) also work well without formation of any side products. — (KAMBLE*, V. T.; MULEY, D. B.; ATKORE, S. T.; DAKORE, S. D.; Chin. J. Chem. 28 (2010) 3, 388-392; Org. Chem. Res. Lab., Sch. Chem. Sci., Swami Ramanand Teerth Marathwada Univ., Nanded 431 606, India; Eng.) — H. Hoennerscheid   30-167
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